This talk is about the optimization of the active noise control system over a three-dimensional (3D) region using more feasible control systems. Active noise control (ANC) reduces the unwanted acoustic noise by generating an anti-noise with secondary loudspeakers. ANC over 3D region, so-called spatial ANC, aims to reduce the unwanted acoustic noise over a continuous 3D region, which utilizes multiple microphones and multiple secondary loudspeakers to create a large-sized quiet zone for listeners in three-dimensional spaces. However, existing spatial ANC techniques are usually impractical and difficult to implement due to the strict hardware requirements and high computation complexity. Therefore, in this talk,  we explore various aspects of spatial ANC, seeking algorithms and techniques to promote the reliability and feasibility of ANC over 3D regions in real-life applications.